The International Space Station Expedition 45 crew patch prominently features the Book of Knowledge situated at the bottom of the patch to represent the foundation of the crew's journey of exploration provided by the past generations of pioneers, scientists and engineers.

The flow of knowledge is represented by the curves radiating from the book, also a symbol for the hard work and innovation necessary to make human spaceflight a reality. The Space Station is represented by a single bright star soaring around the Earth, illuminating the path to more distant targets to be explored in the future on the foundation of knowledge built by the International Space Station. These targets are also featured in the patch - the Moon, Mars and more distant targets seen as small dots of light. Also included in the patch are the name of the six Expedition 46 crew members are written in their native languages.